According to Somali military officials, the attack took place near the town of Bilis Qooqani hours ago, Press TV reported on Saturday.
Washington claims the airstrikes target militants, though most such attacks have resulted in civilian casualties in Somalia.
The developments come as witnesses say hundreds of Somali families are fleeing from the troubled area.
Drone strikes in Somalia make the lawless state the sixth country where the US military has used remote-controlled aircraft to conduct such lethal strikes.
The US has deployed bombing and intelligence drones in Afghanistan, Pakistan, Libya, Iraq and Yemen to launch aerial missile attacks.
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